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Enhance your expertise with our continuing education programs for dental professionals. Topics include advanced restorative techniques, preventive care strategies, and the latest dental technology. Stay ahead with our expert-led webinars, hands-on workshops, and valuable resources.

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Solventum's School of Purification educates topics such as biopharmaceutical purification, anion exchange chromatography & recombinant protein production.

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Explore our library of peer-reviewed articles, technical documents, brochures and resources developed by our experts on trends and topics relevant to you and the industry.

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Supported by a variety of formats, configurations and media types, Zeta Plus depth filters can meet your needs, from the simple to the complex. Explore the possibilities by process stage, grades or pore size.

Depth filters differ from membrane filters in that they do not have a defined, or absolute, pore size. Membrane filters use mechanical sieving alone, having holes or pores in the surface of the filter that trap objects larger than the pores while letting smaller objects flow through. Depth filters, on the other hand, rely on a combination of materials and thickness to create a maze or tortuous pathway to tap the suspended particles.

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Understanding the intricate demands of harvest and clarification processes across a multitude of applications, we partner closely with manufacturing, process and engineering professionals across diverse industries to find the right solutions for applications with the right specifications, with ease. Drawing from decades of expertise in this essential technique, our extensive range of depth filters, available in various formats, media, grades, and sizes, caters to your critical needs.

3M™ Zeta Plus™ VR Series Filter Media provide an economical solution for viral burden reduction and are used in various bioprocess applications.

Plasma fractionation has led to the creation of numerous therapies over the last several decades, but some process steps have remained largely unchanged in that time. Innovation in certain process steps can lead to overall gains reflected in your yield, purity and bottom line. In depth filtration for plasma fractionation, many downstream stages have shifted to cartridges or single-use technologies. These formats are fully scalable, using differentiated media and an underlying technology that has been used for decades in the plasma industry. With 3M™ Zeta Plus™ Filter Media designed for plasma fractionation, you can select from LA, SP, VR or LP Series Media, each available in all formats. Reach out to one of our experts to identify the best solution for your process needs.

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Distillation

As you work with higher density cell cultures providing higher titers in your biopharmaceutical manufacturing processes, your ability to harvest cell culture consistently and effectively becomes more challenging. Our fiber non-woven chromatographic clarification solutions can help streamline your production process, removing more impurities earlier in your process.

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While gene therapy manufacturing often mirrors processes used for mAbs and recombinant protein manufacturing, they present new challenges and manufacturing bottlenecks that that we can help you overcome with our expertise and experience.

What isfiltration

Deep within your bioprocessing journey, depth filtration takes the stage, removing particles and impurities to uphold product purity and yield. You need reliable, proven solutions that optimize process performance and uphold product quality no matter the market you serve, whether it's pharmaceuticals, biotechnology, and beyond.

3M™ Zeta Plus™ LA Series Filter Media is the cleanest Zeta Plus filter media family offered. These low aluminum filter media are designed to provide low levels of extractables.

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Depending on the process, a mAb purification train will traditionally use a two-stage depth filter process. The filter(s) used in the first stage have a wider nominal pore size to remove larger cells and insoluble fragments. The fluid is then fed into a filter with narrower nominal pore size to remove finer debris. Depth filters with a certain level of positive charge may also remove some negatively charged DNA and host cell protiens.

We can help you address these trends in cell culture purification while driving efficiency in your biopharma manufacturing, whether you are using depth filtration or next-generation technologies like our fiber chromatographic clarification solutions.

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3M™ Zeta Plus™ Activated Carbon Series Filter Media excel in decolorization and removal of specific contaminats, eliminating the need for handling bulk carbon powder.

Microfiltration

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The Zeta Plus encapsulated system filter capsules retain the lenticular filter design and vertical flow path that are characteristic of traditional depth filtration systems. The full range of filter capsule sizes meets your needs from benchtop to production, enabling you to use the same filtration media from the lab through pilot testing and into scale-up.

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Depth filtration utilizes the thickness, of depth of the filter media to trap insoluble suspended particles, separating them from the process fluid that passes through the media. Particles are captured by various mechanisms through the tortuous or complex path of media, including direct interception, inertia, impactation and electrostatic adsorption.

3M™ Zeta Plus™ ZB Series Filter Media offer a higher charge level and smaller nominal pore sizes than SP or LA series and are available in single layer and dual layer grades.

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Culligan's HE Water Softeners are the world's most efficient, helping you save up to 46% on salt, water and electricity usage.

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Free continuing education for nurses, infection preventionists, sterile processing managers and other health care professionals. Solventum medical course topics include: infection prevention, skin care and wound care best practices and guidelines for improving patient outcomes.

3M™ Zeta Plus™ Delipid Series Filter Media are tailored for selective removal of lipids and hydrophobic substances across a variety of bioprocess applications.

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Filtration and clarification are vital to many of your processes, and depth filtration plays an important role. Whether you want to streamline your development of a new process or improve the efficiency and output of an existing one, our products can solve your filtration needs across your biomanufacturing operations. The range of options we offer in media, grade and pore size, with the option to use different media grades in two-stage clarification processes, means you can find the right filtration approach to meet your needs. We know you are experts at optimizing your manufacturing workflows; let our team help you explore new opportunities for efficiency and flexibility as the industry evolves to the bioprocesses of tomorrow.

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Relative to cartridges in stainless steel housings, capsules can save valuable labor time and cost for changeouts, while eliminating the need for cleaning validation. And, when your team is ready to scale, our scalable capsule formats can help you take your processes from pilot and clinical production to commercial and large-scale production efficiently. Production-scale capsules are available in both standard polycarbonate and alkaline-resistant* materials. Their self-guiding locking mechanism ensures fast and reliable capsule-to-capsule connection. The polycarbonate capsules also feature a translucent shell that allows for easy fluid level observation, enabling real-time monitoring of your filtration process.

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3M™ Zeta Plus™ Filter Media SP Series Filter have the widest nominal pore size range relative to other 3M™ Zeta Plus™ Filter Media offerings, including a greater number of grades as well as grades with larger nominal pore size than LA or ZB media.

Solventum's School of Purification educates topics such as biopharmaceutical purification, anion exchange chromatography & recombinant protein production.

Boost your efficiency with Zeta Plus encapsulated system scale-up filter capsules, designed to streamline cell clarification, reduce labor time and improve your operating costs, and are available in both single layer and dual layer design. Our dual layer technology offers enhanced contaminant holding capacity, effectively trapping larger particles upstream and smaller particles downstream. This innovative approach minimizes premature plugging, extending the service life of your media.

Naturalfiltration

Depth filtration is a mainstay for recombinant protein harvest and clarification — but not all depth filter systems are the same. Bioprocessing is increasingly challenged with higher-titer cell cultures, increased contaminants and other developments which make optimizing each step in your process critical. You can transform your recombinant protein manufacturing process with solutions from Solventum. Our Zeta Plus depth filters are a portfolio of scalable, easy-to-handle depth filter solutions. Offering a variety of nominal pore sizes and media characteristics, there’s one to fit your process needs.

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Single-layer depth filters contain only a single layer of filtration media. 3M™ Zeta Plus™ EXT Series Filter Capsules and Cartridges have a dual-layer configuration with two distinct layes or zones of filter media. This construction increases the holding capacity of the filter, extending its service life and providing enhanced clarification for biological fluids. In some processes, using two or more single-layer depth filters in a chain may be advantageous, as each filter can serve a specific purpose that might not be possible with a dual-layer filter.

Depth filters are typically composed of three components: cellulose, a filter aid and a polymer binder resin. Functional chemistry can also be applied to the material for enhanced performance.

Explore our Zeta Plus depth filters solutions across diverse formats, media and configurations to optimize your filtration process for sustained performance.

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Our solutions help you meet your filtration needs, targeting both small molecule applications and active pharmaceutical ingredient (API) manufacturing.

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