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Feature papers represent the most advanced research with significant potential for high impact in the field. A Feature Paper should be a substantial original Article that involves several techniques or approaches, provides an outlook for future research directions and describes possible research applications.

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Ong HW, Drewry DH, Axtman AD. CK2 Chemical Probes: Past, Present, and Future. Kinases and Phosphatases. 2023; 1(4):288-305. https://doi.org/10.3390/kinasesphosphatases1040017

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Ong HW, Drewry DH, Axtman AD. CK2 Chemical Probes: Past, Present, and Future. Kinases and Phosphatases. 2023; 1(4):288-305. https://doi.org/10.3390/kinasesphosphatases1040017

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Care taken to minimise bacterial growth in the pipe system often makes it necessary to establish circulation of domestic hot water at a higher temperature. Systematically increasing the temperature in the domestic hot water system makes it possible to destroy some of the undesired bacteria. In larger domestic hot water systems, circulation may conveniently be managed by a BMS.

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Domestic hot water in pipes will cool due to heat loss when there has not been a withdrawal for quite some time. Circulation of domestic hot water ensures a flow inside the pipes, even though hot water is not withdrawn.

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Ong, Han Wee, David H. Drewry, and Alison D. Axtman. 2023. "CK2 Chemical Probes: Past, Present, and Future" Kinases and Phosphatases 1, no. 4: 288-305. https://doi.org/10.3390/kinasesphosphatases1040017

Ong, H.W.; Drewry, D.H.; Axtman, A.D. CK2 Chemical Probes: Past, Present, and Future. Kinases Phosphatases 2023, 1, 288-305. https://doi.org/10.3390/kinasesphosphatases1040017

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Abstract: Protein kinase casein kinase 2 (CK2/CSNK2) is a pleiotropic kinase involved in many cellular processes and, accordingly, has been identified as a potential target for therapeutic intervention for multiple indications. Significant research effort has been invested into identifying CK2 inhibitors as potential drug candidates and potent and selective CK2 chemical probes to interrogate CK2 function. Here, we review the small molecule inhibitors reported for CK2 and discuss various orthosteric, allosteric, and bivalent inhibitors of CK2. We focus on the pyrazolo[1,5-a]pyrimidines and naphthyridines, two chemotypes that have been extensively explored for chemical probe development. We highlight the uptake and demonstrated utility of the pyrazolo[1,5-a]pyrimidine chemical probe SGC-CK2-1 by the scientific community in cellular studies. Finally, we propose criteria for an ideal in vivo chemical probe for investigating CK2 function in a living organism. While no compound currently meets these metrics, we discuss ongoing and future directions in the development of in vivo chemical probes for CK2. Keywords: protein kinase CK2; CSNK2A1; CSNK2A2; chemical probe; pyrazolopyrimidine; naphthyridine; orthosteric; allosteric; bivalent

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Domestic hot water in pipes will cool due to heat loss when there has not been a withdrawal for quite some time. In large domestic hot water systems, where the distribution piping is extensive, it will take a relatively long time to remove this cool water from the pipes before the hot water can be withdrawn. Due to comfort issues, this is often not acceptable.

Ong, H.W.; Drewry, D.H.; Axtman, A.D. CK2 Chemical Probes: Past, Present, and Future. Kinases Phosphatases 2023, 1, 288-305. https://doi.org/10.3390/kinasesphosphatases1040017

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Circulation of domestic hot water ensures a flow inside the pipes, even though hot water is not withdrawn. In this way, the waiting time is kept to an acceptable level. The domestic hot water is circulated at a given minimum temperature to minimise energy consumption. This is controlled by a circulation valve, strategically placed several places in the domestic hot water system. A circulator pump is used to keep the domestic hot water circulating back to the production system (heat exchanger or water heating unit).

Feature papers are submitted upon individual invitation or recommendation by the scientific editors and must receive positive feedback from the reviewers.

Ong, Han Wee, David H. Drewry, and Alison D. Axtman. 2023. "CK2 Chemical Probes: Past, Present, and Future" Kinases and Phosphatases 1, no. 4: 288-305. https://doi.org/10.3390/kinasesphosphatases1040017

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Editor’s Choice articles are based on recommendations by the scientific editors of MDPI journals from around the world. Editors select a small number of articles recently published in the journal that they believe will be particularly interesting to readers, or important in the respective research area. The aim is to provide a snapshot of some of the most exciting work published in the various research areas of the journal.

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